A year has passed since House crashed his car into Cuddy's home, and we find House spending time behind bars at the East New Jersey Correctional Facility under the close watch of the prison warden. When an antagonistic prison gang leader makes a serious threat, House solicits the help of a fellow inmate, but when another inmate's unusual medical symptoms spark his curiosity, House must come up with creative ways to treat the patient while navigating prison rules. House meets Dr. Jessica Adams, a young, intelligent and bright-eyed clinic doctor, but when they are faced with a controversial opportunity to diagnose the patient's life-threatening illness, Adams is confronted with a choice to trust House and put her career on the line or play by the book.